American Tegumentary Leishmaniasis: Is Antimonial Treatment Outcome Related to Parasite Drug Susceptibility?
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منابع مشابه
American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility?
BACKGROUND Antimonials are the first drug of choice for the treatment of American tegumentary leishmaniasis (ATL); however, their efficacy is not predictable, and this may be linked to parasite drug resistance. We aimed to characterize the in vitro antimony susceptibility of clinical isolates of Peruvian patients with ATL who were treated with sodium stibogluconate and to correlate this in vitr...
متن کاملInfluence of Leishmania (Viannia) species on the response to antimonial treatment in patients with American tegumentary leishmaniasis.
BACKGROUND Pentavalent antimonials (SbV) are the first-line chemotherapy for American tegumentary leishmaniasis (ATL). There are, however, reports of the occurrence of treatment failure with these drugs. Few studies in Latin America have compared the response to SbV treatment in ATL caused by different Leishmania species. METHODS Clinical parameters and response to SbV chemotherapy were studi...
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INTRODUCTION American tegumentary leishmaniasis (ATL) can affect the skin or mucosa (mucocutaneous leishmaniasis - MCL) including the oral cavity. MCL oral lesions are often confused with other oral diseases, delaying diagnosis and specific treatment, and increasing the likelihood of sequelae. Thus, increasing the knowledge of the evolution of ATL oral lesions can facilitate its early diagnosis...
متن کاملClinical and parasite species risk factors for pentavalent antimonial treatment failure in cutaneous leishmaniasis in Peru.
BACKGROUND Treatment for cutaneous leishmaniasis (CL) with standard pentavalent antimonial therapy is hampered by cumbersome administration, toxicity, and potential failure. Knowledge of factors influencing treatment outcome is essential for successful management. METHODS A case-control study of incident cases was performed with patients experiencing their first CL episode. The standard treat...
متن کاملParasite, vectors and reservoirs as determinants of tegumentary leishmaniasis.
1. Serviço de Imunologia, Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, BA. Address to: Dr. Edgar Marcelino Carvalho. Serviço Imunologia/HUPES/UFBA. Rua João das Botas s/no, Bairro Canela, 40110-160 Salvador, BA, Brasil. e-mail: [email protected]; [email protected] Phone: 55 71 3237-7353 Received in 01/08/2012 Accepted in 06/08/2012 Parasite, vectors and reser...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2006
ISSN: 0022-1899,1537-6613
DOI: 10.1086/507710